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10.1158/1055-9965.Epi-12-0229 35 DugnaniE.GandolfiA.BalzanoG.ScaviniM.PasqualeV.AleottiF.et al (2016)
They found that iron, ACSL4, and MDA levels increased with increasing reperfusion time, with concomitant decreases in GPX4 levels, and deferoxamine treatment significantly ameliorated myocardial injury [88]
This has been a central theme of my Muscle-Centric Medicine framework, and its why Ive always pushed back against the idea that OA is simply the price of aging or carrying extra weight
In this framework, the redox bottleneck represents a potential inflection point at which oxidative throughput approaches the regenerative capacity of NAD/NADPH-dependent buffering systems
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